By Justin Farris

Phosphorus Scientists to Present Early Findings from Large-Scale FertilityMap Study at the ASRM Scientific Congress

Research demonstrates progress towards developing predictive algorithms to inform infertility diagnosis, prognosis, and treatment to help the 1 in 6 couples impacted by infertility.

We will present findings from our large-scale FertilityMap research study at the American Society for Reproductive Medicine (ASRM) Scientific Congress in Salt Lake City this week. FertilityMap is a first-of-its-kind, IRB-approved study utilizing genomics and big data to bring clarity to the infertility journey. The goal of the study is to develop predictive algorithms to inform infertility diagnosis, prognosis, and treatment in both males and females to ultimately improve pregnancy success rates.

While a wealth of research has demonstrated that genetics play a critical role in infertility diagnosis and treatment outcomes, the translation of these findings from the bench to bedside has lagged. Our scientists will present three abstracts at this year’s event. The abstracts highlight efforts to unravel the complex nature of infertility using large populations and datasets and to develop new advanced methodologies for infertility diagnosis:

  • “FSHR Ser680Asn: Correlation with FSH Levels.” Presents preliminary analysis of fertility potential in women using genetic data, and validates results previously shown in the literature. (O-200. Sara Bristow, Ph.D., Wednesday, October 19 at 11:30am).
  • “What Influences Anti-Müllerian Hormone Levels?” A complex analytical strategy reveals combinations of single nucleotide polymorphisms in key hormone signaling genes, which affect serum hormone levels. (P-594 Sara Bristow, Ph.D, Wednesday Oct 18 at 7:00am).
  • “Detecting Y-Chromosome Microdeletions using Next Generation Sequencing (NGS) Data.” Discusses a new methodology to detect Y-chromosome microdeletions, a common cause of oligospermia and azoospermia. Utilizing next-generation sequencing and computational algorithms, it is possible to detect Y-chromosome microdeletions at high resolution. (P-321. Roman Shraga, Tuesday, October 18 at 7:00am).

Phosphorus is partnered with Recombine, a CooperSurgical company and a leading provider in genetic testing for reproductive health, to conduct the FertilityMap study. Together with more than 20 top IVF clinics across the country, we have enrolled thousands of patients to date. The power of the FertilityMap study comes from it’s uniquely comprehensive scope, analyzing hundreds of clinical variables and thousands of genetic variants in the context of each participant’s personal and family medical history.

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